Philanthropy can play a unique role in backing rapid-turnaround science at UCSF, especially in times of heightened need. In the last year, the newly renamed Sandler Program for Breakthrough Biomedical Research, or PBBR, has helped UCSF researchers launch COVID-19 testing and public health initiatives in hard-hit San Francisco neighborhoods, now a national model for pandemic response. Funds have also helped uncover potential drug targets to fight SARS-CoV-2 infection, and driven the development,