DNA聚合酶是负责DNA复制、修复和重组的关键酶，其复制保真度对维持基因组稳定性和预防疾病至关重要。DNA聚合酶通过动力学校对实现高保真度，其复制错误率可低10-6，然而，受限于传统的“开放-闭合”二态模型,该机制尚未成功应用于量化聚合酶的保真度。近 ...

Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...

There’s been this dream for decades. What if we could just print out an entire gene directly, one base at a time? —Daniel Lin-Arlow, Ansa Biotechnologies As scientists set their sights on cell and ...